Of ephedrine on cerebral ischemia reperfusion injury in rat brain astrocytes in GFAP expression.docVIP

 PAGE \* MERGEFORMAT 12 Of ephedrine on cerebral ischemia reperfusion injury in rat brain astrocytes in GFAP expression [Abstract] Purpose cerebral ischemia reperfusion injury of astrocytes ephedrine treatment on glial fibrillary acidic protein (GFAP) expression. Methods 60 male SD rats were randomly divided into sham operation group, the natural recovery group and treatment group. The unilateral application of suture method of middle cerebral artery ischemia-reperfusion model, after 1,2,3,4 weeks of observation of ischemia by immunohistochemical expression of GFAP around the area. the result of natural recovery group and treatment group after 1 week GFAP expression began to increase after 3 weeks the expression of smooth. GFAP expression levels of the treatment group the first two time points higher than the natural recovery group (P lt;0.05). Conclusions of ephedrine on cerebral ischemia ischemia reperfusion injury around the proliferation of activated astrocytes can promote. [Keywords:] ephedrine, cerebral ischemia, astrocytes, glial fibrillary acidic protein (GFAP), rat ABSTRACT: Objective To investigate the effects of ephedrine on glial fibrillary acidic protein (GFAP) expression after cerebral ischemia-reperfusion injury in rats. Methods Altogether 60 male SD rats were randomly divided into sham-operation group, natural recovery group and ephedrine treatment group. The unilateral ischemia-reperfusion models were induced by clue-blocked method. The expression level of GFAP around ischemic area was examined by immunohistochemical technique at weeks 1, 2, 3 and 4 after operation. Results GFAP expression began to increase at 1 w and stabilized at 3 w in ephedrine treatment group and natural recovery group. There was a significant increase of GFAP expression in ephedrine treatment group compared with that in natural recovery group (P lt;0.05) at the first two time points. Conclusion Ephedrine treatment facilitates the activation and proliferation of a