On the drug resistance of Mycobacterium tuberculosis detection.docVIP

 PAGE \* MERGEFORMAT 13 On the drug resistance of Mycobacterium tuberculosis detection [Abstract] Application of anti-TB drugs in the treatment of tuberculosis, the most concern is that clinicians bacterial resistance. Because the treatment of Mycobacterium tuberculosis on the inevitable emergence of drug resistance, and impact of TB treatment. So as refractory tuberculosis. [Keywords:] anti-TB drug resistance testing To enable anti-TB drugs on the treatment of tuberculosis to achieve the desired results, the first in the application of drug therapy, several issues need to know: First, the inhibitory concentration in vitro Joined the anti-TB drugs within the medium, inoculation of bacteria to see how much concentration of drug to inhibit the growth of bacteria, find the minimum inhibitory concentration (MIC), MIC is the clinical basis for determining therapeutic drug dosage. For anti-TB drugs MIC, see the basis of short-course chemotherapy of bacteriology. Application of different media measured by the difference in inhibitory concentration. If LJ medium inhibitory concentration of the measured liquid medium or semi-fluid medium than the measured inhibitory concentration high. Vigorous growth of bacteria in the development of drug-sensitive, when the growth of bacteria in the developmental period of rest in sleep that is not present inhibitory effect of drug. Based on the rise and fall phase of bacterial growth and development, constitute the basis for treatment of pulmonary tuberculosis. Second, the drug concentration in blood Determination of blood concentration of anti-TB drugs is the study of drugs in the body’s absorption and excretion, the relationship between efficacy and toxicity, body fluids of drug content and distribution, the effective inhibitory concentration of bacteria. To determine effective treatment of drug dose and frequency of medication . Because the type and incidence of tuberculosis