On the clinical treatment of bleeding disorders.docVIP

 PAGE \* MERGEFORMAT 6 On the clinical treatment of bleeding disorders [Abstract] hemorrhagic disease is occurring because the normal mechanism of hemostasis disorders, clinical manifestations of spontaneous bleeding or bleeding after minor injuries to a group of diseases. Pathogenesis of three factors: ① the abnormal blood vessels. ② the qualitative and quantitative platelet exception. ③ abnormal clotting mechanism. hemorrhagic disease refers to the normal hemostatic disorder in the unusual circumstances caused by the vessel wall abnormalities, platelet count or dysfunction, caused by coagulation dysfunction, manifested as spontaneous bleeding or bleeding after minor injury beyond. Since bleeding is a complex concept, emergency caused by bleeding in the diagnosis of patients more likely to neglect or delay, so the correct diagnosis and treatment of bleeding must be based on understanding of the mechanisms of blood coagulation. [Keywords:] treatment of bleeding disorders of platelet Classification of bleeding disorders 1. Vessel wall abnormalities (1) hereditary: hereditary telangiectasia, familial purpura simplex. (2) acquired: infection, chemicals, drugs, metabolic factors. (3) Allergic: anaphylactoid purpura. (4) Other: simple purpura, mechanical purpura, senile purpura and so on. 2. Platelet abnormalities (1) thrombocytopenia: ① decreased production, AA, AL, infection, drugs, ② too much damage, ITP, ③ excessive consumption, thrombotic thrombocytopenic purpura, DIC, etc.. (2) thrombocytosis: ① primary, essential thrombocythemia, ② secondary, secondary to CML after splenectomy, infection, trauma and so on. (3) platelet function defect: ① genetic, Glanzmann thrombasthenia, giant platelet disease, idiopathic thrombocytopenic patients. ② secondary, secondary to drugs, uremia, liver disease. 3. Coagulopathy (1) hereditary: hemophilia A and hemophilia B, FXI deficiency, prothrombin deficiency, low afibrinogenemi