On the analysis of 18 cases of acute paraquat poisoning.docVIP

On the analysis of 18 cases of acute paraquat poisoning [Paper Keywords] paraquat; poisoning; multiple organ failure [Abstract] Objective: To explore the pathogenesis of paraquat poisoning, clinical manifestations and treatment methods. Methods: A retrospective analysis of 18 cases of paraquat poisoning in clinical data. Results: 14 patients died, the mortality rate was 77.8%, of which 11 patients died of multiple organ failure. Conclusions: Paraquat poisoning can lead to multiple organ failure, higher mortality rates, early blood perfusion, high-dose corticosteroids, the use of immunosuppressive agents help improve success rate of resuscitation. Paraquat (paraquat, also known as paraquat), its 20% solution also known as Paraquat is a highly toxic class of organic heterocyclic contact herbicide, there is a certain degree of corrosion, weeding good effect in recent years, to widely used in rural areas, if in the course of improper operation, wrongly or suicide taking may result in poisoning, in critical condition, a high fatality rate [1]. Now in our hospital from 2004 to 2007 oral paraquat poisoning patients admitted 18 patients with the information reported is as follows. 1 Data and methods 1.1 General Information: 18 patients, 8 males and 10 females; aged 16 to 60 years with an average age of 35, oral 20% ~ 25% Paraquat Concentrate 5 ~ 50 ml, medication to treatment time of 1 h ~ 2 d. 1.2 Clinical manifestations: the emergence of these patients had varying degrees of gastrointestinal symptoms such as nausea, vomiting, abdominal pain, difficulty swallowing, in which 14 patients with respiratory failure, toxic myocarditis in 2 cases, gastrointestinal bleeding in 9 cases, 4 cases of abnormal liver function, renal insufficiency 8 cases, multiple organ failure in 13 cases. 1.3 Laboratory tests: abnormal liver function changes in four cases: TBIL 25 ~ 206 μ mol / L, ALT 62 ~ 350 U / L, AST 50 ~ 198 U / L, renal dysfunction, 8 cases: Cr 446 ~ 980 μ mol /