On non-syndromic cleft lip with or without cleft palate in the genetic pattern.docVIP

 PAGE \* MERGEFORMAT 18 On non-syndromic cleft lip with or without cleft palate in the genetic pattern Of: WANG Yun Yong Zhu Wenli Guo Jinzhen Song Xiaoming Li Shuqin [Abstract] Objective To investigate the non-syndromic cleft lip with or without cleft palate in the genetic approach, its high pedigrees for genetic studies. Methods segregation analysis and polygenic threshold model analysis of 37 non-syndromic cleft lip with or without cleft palate pedigree with high incidence analysis. The results of the relatives of probands were first-degree relatives the prevalence was 29.89% (26/87), second-degree relatives was 2.70% (4 / 148); their relatives correlated with the incidence of distant blood relations in the past related to blood relationship with the proband relatives of the more recent prevalence rate is higher; non-syndromic cleft lip with or without cleft palate is different from the mode of inheritance of single gene autosomal dominant, recessive Genetic and sex-linked genetic, and consistent with polygenic inheritance, and its primary, secondary genetic relatives of the weighted average was (148.40 + -8.20)%. Conclusions The non-syndromic cleft lip with or without cleft palate as a polygenic mode of inheritance . [Keywords: non-syndromic cleft lip with or without cleft palate; single gene inheritance; multiple genetic; Heritability [Abstract] Objective To study the mode of inheritance of nonsyndromic cleft Lip and / or palates (NSCL / P). Methods37 families with NSCL / P were studied using segregation analysis method and polygenic threshold analyzing method.ResultsThe prevalence of NSCL / P in primary relatives was 29.89% (26/87), and was 2.70% (4 / 148) in secondary relatives.The prevalence of NSCL / P in relatives is related to the extent of the consanguinity. The higher the extent of the relation to the proband is, the higher the prevalence is. The inheritance mode of NSCL / P is quite different from monogenes autosomal dominant (AD), aut