Oxygen free radicals and ischemic stroke.docVIP

 PAGE \* MERGEFORMAT 14 Oxygen free radicals and ischemic stroke [Abstract] A recent study found that ischemic stroke can lead to excessive production of oxygen free radicals, leading to brain cell damage, causing neurological defects. Therefore, the generation of free radicals to prevent cerebral ischemia on the protection of nerve function after ischemia is important. In this paper, oxygen free radicals produced in ischemic stroke, may cause damage and how interventions are reviewed. [Keywords:] oxygen free radicals, ischemic stroke, intervention Oxygen free radicals (Oxygen Free Radical, OFR is present in the cells produced by the aerobic metabolism of a class of active groups. Including superoxide anion, hydroxyl radical, nitric oxide radical, lipid peroxide free radicals. Because of its oxygen atoms with unstable, and therefore, more active chemical activity, also known as reactive oxygen species (Reactive Oxygen Species, ROS. In recent years the field of basic medicine and life science research results show that after ischemic stroke may produce large amounts of ROS, resulting in neuronal damage and neurological deficit. Therefore, how to prevent ischemic stroke ROS generation and ROS on neuronal damage has become a hot research, and obtained many significant research results. 1, the generation of oxygen free radicals Under normal circumstances, the brain cells of oxygen free radical production and elimination of dynamic equilibrium, because the memory in the brain cells of oxygen in a very strong free radical defense system, including superoxide dismutase (superoxide dismutase, SOD), have catalase (catalase, CAT), glutathione (glutathione hormone, GSH), cytochrome oxidase endogenous antioxidant system, aerobic metabolism with cellular ROS produced by the organic combination of the ROS transformed into Cell harmless substances, protect the structure and function of brain cells. As the body of aerobic metabolism in the brain is the organ of