P16 protein in cervical and endometrial adenocarcinoma differential diagnosis of adenocarcinoma.doc

 PAGE \* MERGEFORMAT 16 P16 protein in cervical and endometrial adenocarcinoma differential diagnosis of adenocarcinoma [Abstract] Objective To observe the p16 protein in cervical adenocarcinoma and endometrial adenocarcinoma and its significance in differential diagnosis. But will also guide the clinical part of the early cases the need to retain reproductive function. Methods Immunohistochemistry chemical SP method detected in 40 cases of cervical adenocarcinoma and 73 cases of endometrial adenocarcinoma in the p16, p53, ER and PR expression. Results (1p16 in 40 cases of cervical adenocarcinoma in 37 patients (92.5% showed diffuse positive, in 73 cases of endometrial adenocarcinoma in 28 cases (38.4% were focally positive. (2 in cervical adenocarcinoma in the p53, ER, PR positive expression of each 20.0%, 5.0%, 7.5% in endometrial cancer, 38.4% in the expression of p53-positive, hormone receptor ER, PR in endometrial adenocarcinoma were 78.1%, 71.2% of expression. p16 protein in cervical adenocarcinoma showed diffuse nuclear and cytoplasmic positive, but histology Similar endometrial morphology and irregular focal positive for adenocarcinoma, and the overall intensity is weak. p16 protein in both the United p53 protein detection, hormone receptors ER, PR will not only be able to identify cervical cancer and endometrial cancer, can also be used for uterine serous carcinoma and differential diagnosis of endometrial adenocarcinoma. Conclusion of uterine cancer biopsy or curettage specimens, p16 protein detection can be used as a complementary immunohistochemical markers to identify cervical cancer and endometrial adenocarcinoma. [Keywords:] cervical adenocarcinoma, the differential diagnosis of endometrial adenocarcinoma p16 [Abstract] Objective: TObjectives Observation of p16 protein in cervical adenocarcinoma and endometrial cancer in the differential diagnosis of significance. Also part of the guideline on early cases whether the fertility pres