p27Kip1 and tumor.docVIP

 PAGE \* MERGEFORMAT 22 p27Kip1 and tumor Eukaryotic cell cycle progression is ordered by a series of regulatory factors to regulate the aggregation and activation control, its normal or not, and cell and individual growth, differentiation, aging and cancer are closely linked. Involved in cell cycle regulation of the main elements are: cell cycle protein (cyclin), cyclin-dependent kinase (cyclin dependent kinases, CDKs) and CDK inhibitors (cyclin dependent kinase inhibitors, CDKI). Which CDKI proteins with the cell cycle, CDK or the cyclin-CDK complex by binding and inhibiting CDK activity, leading to cell cycle arrest, blocking the process of cell proliferation. CDKI discovered so far by the different structure and function is divided into two categories: one category Ink4 (Inhibitor of cdk4), including p16, p15, p18, and p19, the protein structures were hooked back with four repetitive sequences, specifically inhibited by cyclin kinase activity D-CDK4/CDK6 phosphorylation. And those for the Cip / Kip (CDK-interacting protein / kinase inhibition protein), including p21 Cip1, p27 Kip1, p57 Kip 2 and so on. They have a C-terminal nuclear localization signal, and there is a near amino-terminal conserved region. This group of proteins can be widely applied to a variety of cyclin-CDK complexes, to play its inhibitory activity. As the biochemical function and regulation of CDKI way, decided to grow their important stage in the cell plays an important role. As a CDK inhibitory protein, has proved to be a number of CDKI is a potential tumor suppressor or a tumor suppressor gene. Discovered in recent years, p27 genes and their products for cell growth and has an extremely important role in regulating and, in some tumor tissues and tumor cell lines found in the abnormal expression of p27, suggesting that the occurrence and development of tumor has a close relationship. 1, p27Kip1 gene and its protein In 1994, Polyak et al [1] in the transform