Pathology of common tumors in China.doc

 PAGE \* MERGEFORMAT 11 Pathology of common tumors in China Keywords: common tumor pathology In recent years, the development of tumor pathology is very fast, based on current scientific and technological development can be predicted from the molecular level to clarify the pathology, especially in tumor tissue will be more and more genetic discovery. Is on the esophageal, gastric, colorectal cancer, breast cancer, nasopharyngeal cancer pathology of our common tumors are outlined below. 1 carcinoma histogenesis and pathogenesis of Science 1.1 Gastric Cancer: Gastric carcinogenesis is a gradual process. Histogenesis cancer for many years before the usually manifested continuous precancerous lesions, some scholars believe that from normal mucosa through atrophic gastritis, intestinal metaplasia, dysplasia to intestinal type gastric cancer, is the progressive development of gastric mucosa multi-step process, the first two belong to the precancerous condition, dysplasia belongs to precancerous lesions. Pathological workers in China make crypt dysplasia, regenerative dysplasia, the ball-like shaped glandular dysplasia and cystic nature of the expansion of a precancerous lesion. Using polymerase chain reaction (PCR) and molecular hybridization technique was found, C-Haras gene mutation related to the occurrence of gastric cancer. C-erbB-2 gene amplification were mainly seen in well-differentiated adenocarcinoma, while Sam gene amplification were seen in poorly differentiated adenocarcinoma and scirrhous carcinoma. Adjacent intestinal metaplasia of rasp21, Fesp85 oncogene product concentration increased significantly. That is closely related to intestinal metaplasia and gastric cancer. 1.2 esophageal cancer: the reported 1185 cases of esophageal mucosa 3H〕 〔 dThd labeled material, with an average labeling index of normal epithelium followed by 3.6%, 3.6% spike cell hyperplasia, chronic esophagitis was 4.6%, 4.7% atypical hyperplasia, carcinoma 6.5%. From the esop