Patients with acute cerebral infarction IL6 TNF and stress the relevance of hyperglycemia.doc

 PAGE \* MERGEFORMAT 11 Patients with acute cerebral infarction IL6 TNF and stress the relevance of hyperglycemia Of: Caizhi You Yong Yu Changyin Zhang Jun Yan Zhao Yu Wang Feng-ying Huang Liangguo ni Week [Abstract] Objective To observe the serum of patients with acute cerebral infarction IL 6, TNF @, and stress hyperglycemia, insulin (INS), insulin-like growth factor 1 (IGF 1) the dynamic changes of brain injury patients with acute ischemic inflammatory factors and sugar the relationship between metabolites, researchers stress hyperglycemia in acute ischemic brain injury in the pathophysiology. methods were divided into 5 groups: normal group (N group), Xingding treatment of cerebral infarction group (X group, apricot Dinge aspirin treatment of cerebral infarction group (XA group, low-dose aspirin Xingding insulin treatment of cerebral infarction group (XY group, diabetic control group (D group), each 15 samples. ELISA determination of IL 6, TNF @ , measured by radioimmunoassay in patients with IGF 1, INS, blood chemical analysis. Results X group, XA group, XY group, D group and N group IL 6, TNF @ concentration was significantly higher compared (P lt;0.01,2,24,48 h X group, XA group, XY group, D group compared with the N group was significantly higher blood glucose levels (P lt;0.01,2,24 h X group, XA group, XY group, D group compared with the N group was significantly higher INS concentrations (P lt;0.05, D group and the X group, XA group, XY 2 w group was significantly higher compared IGF 1 concentrations (P lt;0.01. Conclusion Stress hyperglycemia and cerebral ischemia in patients with serum IL 6, TNF @ concentration levels were not correlated ischemic brain damage in acute stress hyperglycemia in no way enhanced by inflammation of the brain damage. [Keywords:] cerebral ischemia, interleukin 6, tumor necrosis factor-@, stress hyperglycemia Ischemic brain injury is a multi-factor, multi-mechanism, and more vicious aspects of the cascade process