Patients with acute leukemia LRP GSTπ MRP1 protein expression and clinical significance of.doc

 PAGE \* MERGEFORMAT 3 Patients with acute leukemia LRP GSTπ MRP1 protein expression and clinical significance of Author: Xiao Zhen Huang Bintao tall, Yan Xiaohong YANG ZHAO Wei Shi Yutao Hasen New [Abstract] This study investigated the glutathione S-transferase  π (GST  π ), multi-drug resistance-associated protein 1 (MRP1), lung resistance-related protein (LRP) and acute leukemia (AL) multi-drug resistance (multi  drug resistance, MDR) of the relationship between these three kinds of resistance and to explore the relevance of protein expression as well as the expression of the three patients with clinical features of the relationship between the AL. The immunohistochemical detection of S  P France 80 cases of AL patients and 30 normal GST  π , MRP1 and LRP expression. The results showed that: GST  π , MRP1, LRP protein expression with clinical drug resistance associated protein expression in three kinds of resistance to the complete remission rate of positive group were lower than the negative group, suggesting that resistance protein expression in leukemia patients when a poor prognosis. GST  π , MRP1 in the refractory group, the expression of AL is highly relevant. Conclusion: GST  π / MRP1 detection in both the joint assessment of poor prognosis of leukemia than the separate determination of a protein, a more significant clinical significance. When the peripheral WBC count ≥ 10 * 109 / L, when, LRP expression was significantly increased, suggesting that the number of LPR for high white blood cell leukemia drug resistance and prognosis in patients with high diagnostic value assessment. [Keywords:] Acute leukemia; glutathione S-transferase  π ; multi-drug resistance-associated protein; lung resistance-related protein; multi-drug resistance Expressions of LRP, GST  π and MRP1 in Acute Leukemia Patients and Its Clinical Significance Abstract This study was purposed to investigate the relationship of expressions of gluthatione 