Pentoxifylline colon-coated tablets Preparation Study.doc

 PAGE \* MERGEFORMAT 11 Pentoxifylline colon-coated tablets Preparation Study [Abstract] Objective To prepare pentoxifylline colon-coated tablets. Preparation of pentoxifylline die in order to drug release in vitro 50% of the time required for the target, using coated tablets by orthogonal design the best prescription. Results The optimum coating prescription: sustained-release layer ingredients Eudragit RL: RS mass ratio of 1:1.5, sustained release layer coating weight gain of 2.0%, enteric coating layer weight gain of 6%, curing time is 3 h . Conclusion of pentoxifylline colon-coated tablets Preparation process is simple, reasonable and feasible. [Keywords:] Pentoxifylline; colon-coated tablets; in vitro release Abstract: Objective To prepare the pentoxifylline enteric  coated tablets for targeting drugs on the colon.Methods The core tablets were prepared and orthogonal design was used to optimize the coating formulation.Results Eudragit RL  RS (1:1.5), 2.0% weight increase of the sustained  release layer, 6% weight increase of the enteric layer, 3 h of the setting time were the optimized coating formulations.Conclusion The preparation procedure of pentoxifylline enteric  coated tablets was simple and practical. Keywords: pentoxifylline; enteric  coated tablets; coating; formulation Pentoxifylline (pentoxifylline, abbreviated PTX) as a vasoactive drugs used for the treatment of vascular insufficiency diseases, in recent years found a strong anti-inflammatory and immune regulatory role. Zhang Bingyong [1] and other people to use pentoxifylline treatment of 2,4,6  TNBS-induced colitis model mice showed that significantly reduced the degree of inflammation, inflammatory index decreased to obtain a better therapeutic effect . Oral colon-specific drug delivery through the oral administration of drug release in the colon, so that a higher drug concentration in parts of the colon, thereby enhancing the therapeutic effect of colonic diseases. In this