Percutaneous coronary intervention of antithrombotic therapy.docVIP

 PAGE \* MERGEFORMAT 6 Percutaneous coronary intervention of antithrombotic therapy Currently percutaneous coronary intervention (Percutaneous Coronary Intervention, PCI) gradual increase in the number of in many countries each year more than 1 million people around the world to conduct PCI. PCI perioperative antithrombotic therapy on the lower PCI-related myocardial infarction, acute or delayed vascular occlusion, need for early emergent CABG or re-line of PCI, as well as the total mortality significance. Antithrombotic therapy goals include: ① to prevent restenosis. To date, in addition to abciximab for diabetes other than the EPISTENT trials, there is no evidence that antithrombotic therapy on the prevention of restenosis, there is a genuine effect; ② the prevention of subacute stent thrombosis. The main drugs aspirin and thienopyridine drugs (ISAR, STARS, FANTASTIC, MATTIS); ③ prevention of acute thrombosis and myocardial infarction. The main treatment measures include aspirin, GP Ⅱ b-Ⅲ a receptor inhibitor, clopidogrel pretreatment, anticoagulant drugs (such as intravenous unfractionated heparin, low molecular weight heparin or pentosan sodium). In this paper, they make the following overview of antithrombotic therapy. An anti-platelet therapy 1.1 Aspirin A number of clinical trials and several meta-analysis has been established inhibitors of cyclooxygenase -1 an important role. Aspirin is the cornerstone of antithrombotic therapy in patients with PCI. Disable PCI in patients with aspirin is dangerous and can increase the bare stent after stent thrombosis risk and the risk of new coronary events [1]. 748 cases of PCI in patients with recently carried out an aspirin study, follow-up of 12 years. The results showed that aspirin treatment group (n = 535 cases, 71.5%) 54 patients died of various causes of death, 20 patients died of sudden cardiac death, and those who did not use aspirin (n = 213 cases) comparison, aspirin can significantly reduce all-