Peritumoral edema in meningioma Progress mechanism.doc

 PAGE \* MERGEFORMAT 17 Peritumoral edema in meningioma Progress mechanism [Keywords:] Meningioma; edema; mechanism Meningiomas are common intracranial tumor, peritumoral edema (p elltumond brain edema, PTBE) is a common complication of meningiomas, the occurrence probability of about 50% ~ 92% [1]. PTBE increased tumor occupying effect, destroyed the blood-brain barrier and local cerebral tissue structure and increased intracranial pressure caused by persistent diffuse, so that prolonged treatment of meningioma patients, so the existence and extent of PTBE can directly affect the rate of disease progression in patients with clinical symptoms and prognosis. However, meningioma peritumoral edema (MPE) occur in the exact mechanism is still not very clear [2], the pathogenesis of MPE and the influencing factors reviewed in the paper. A physical and chemical factors on the important role of MPE 1.1 pial blood supply to the important role in the MPE is generally believed that the current MPE for the vasogenic edema, Ide et al [3] found that the occurrence of PTBE tumor and its surrounding tissue adhesive on only when the blood vessels penetrating intracranial arachnoid or tumor invasion arachnoid accompanied by increased vascular permeability, the tumor tissue edema resulting macromolecules caused by capillary endothelial cells to split the connection point or channel into the tumor stroma, and if the soft membranes and arachnoid Continuity has also been damaged, causing edema and macromolecules into the brain tissue, causing PTBE. Bitzer et al [4] 74 patients with intracranial meningiomas were studied retrospectively and found that edema index EI (EI that tumor volume and edema volume divided by tumor volume, in order to quantify an index of edema) and the soft membrane of blood significant correlation for the grade, the soft film of blood supply and PTBE compliance rate was 96%. a lot of research also found that edema associated with meningioma brai