Pingyangmycin microspheres Preparation and long-acting formulations in vivo release.docVIP

 PAGE \* MERGEFORMAT 10 Pingyangmycin microspheres Preparation and long-acting formulations in vivo release Abstract Objective To prepare the stable long-term drug release microspheres Pingyangmycin preparation of the microsphere preparations investigated in vivo release. Method using double emulsion solvent evaporation method, using poly lactic glycolic acid (PLGA) copolymer as capsule material, will be encapsulated in PLGA microspheres Pingyangmycin, the preparation may release with higher encapsulation efficiency of PLGA Pingyangmycin microspheres long-term preparations. The microsphere preparation in vitro environment and the Beagle a drug release test. Experimental results show that the in vitro release sustained release microsphere preparation Pingyangmycin nearly 28 d, injected into their beagle dogs, the stable release Pingyangmycin nearly 24 d. Conclusion PLGA microspheres preparation Pingyangmycin reasonable preparation, intramuscular injection of the microspheres with sustained release formulations in vivo role of PYM. Keywords: PYM; polylactic acid glycolic acid (PLGA); microspheres; vitro release; vivo release PYM currently mainly used in the treatment of malignant tumors in the elderly and prone to significant effect 1,2. Some benign tumors and benign lesions, such as lymphangioma, hemangioma, Ophthalmic pterygium, skin warts and vitiligo, nasal polyps, etc. in the application of Bleomycin treatment effects were seen satisfactory 3. Due to the limited application of Pingyangmycin short half-life, drug delivery limitations of large clinical application in China, mainly around the administration in place, making the anti-tumor properties of PYM have not been very good application. Be a continuous injection treatment adds to troubles of patients, especially elderly patients is more difficult to sustain a continuous injection of the pain. PLGA (PLGA) copolymer is a drug commonly used in pharmaceutical formulations prepared materials,