Phenobarbital allergy-related type 1 diabetes mellitus.doc

 PAGE \* MERGEFORMAT 15 Phenobarbital allergy-related type 1 diabetes mellitus [Abstract] Objective anticonvulsant drug allergy syndrome (AHS) is an acute fatal disease. It occurs with aromatic anticonvulsant drugs aromatic oxide metabolites in the class. Usually 2 to 8 weeks after medication occurred, but by fever, rash, swollen lymph nodes and visceral damage to the typical understanding of diagnosis before being displayed. In this paper, a case report and literature review to explore the relevance of phenobarbital allergy type 1 diabetes mellitus (T1DM) the clinical manifestations, diagnosis and treatment. Methods of T1DM phenobarbital allergy-related Case reports and literature review. Results 1 cases of 5-year-old girl was taking phenobarbital, 13 days after the fever, rash, non-viral hepatitis and elevated serum IgE, the application of corticosteroids and other anti-allergy, the condition has improved, however, the onset of 4 weeks occurs around polydipsia, polyuria, dehydration and with increased anion gap (33.3mmol / L) of the severe metabolic acidosis (-26.3mmol / L) performance, high blood glucose (31.2 mmol / L), high blood ketone (4.7mmol / L), higher glycosylated hemoglobin (7.2%), low insulin (4.3mmol / L) and low C-peptide (0.6mmol / L) in children diagnosed with type 1 diabetes combined, plus insulin replacement therapy and high-dose gamma globulin therapy significant improvement in condition after in hospital 45 days after discharge, continued application of insulin (Novo and forest 30R morning and afternoon, respectively 10IU and 4IU). Discharge follow-up of 1 year in stable condition, continuing to add exogenous insulin, was discharged 1 month review of high glycated hemoglobin was 7.3%. Search in English literature, only 1 case was reported in adults associated with the AHS outbreak of T1DM, the anti-epileptic drugs carbamazepine. Conclusion The incidence of AHS is very low, but in taking the aromatic anticonvulsants (including phenobarbita