Plasma homocysteine ET and NO levels associated with hypertensive disorders in pregnancy study.doc

 PAGE \* MERGEFORMAT 10 Plasma homocysteine ET and NO levels associated with hypertensive disorders in pregnancy study Of: Zhang Huiping, Shi Qing, Zhang Italy, Yang Xuemin [Abstract] Objective To investigate plasma homocysteine #8203;#8203;(Hcy) and pregnancy induced hypertension (PIH) relationship and endothelin (ET) and nitric oxide (NO) in the role of PIH. Methods 90 patients with PIH , in which pregnancy-induced hypertension 36 cases of non-eclampsia, preeclampsia (mild), 30 patients with preeclampsia (severe) group, 24 cases; and randomly selected the same period 40 cases of normal late pregnancy for the control group. were fluorescent polarization immunoassay method for the determination of plasma homocysteine #8203;#8203;levels, by radioimmunoassay and chemical plasma ET and NO were detected. Results of plasma Hcy in patients with pregnancy induced hypertension and ET levels were significantly higher and plasma NO were significantly lower than the control group (P lt;0.05), with preeclampsia (severe) group increased significantly, plasma Hcy levels and ET was positively correlated, and negatively related to NO. Conclusion HDCP abnormal elevation of plasma Hcy caused a blood vessel endothelial injury, ET and NO reduced the abnormal increase, leading to dysfunction of ET and NO, blood pressure, may promote the formation of hypertensive disorders in pregnancy is one important mechanism. [Keywords:] pregnancy induced hypertension, homocysteine, endothelin, nitric oxide Abstract: Objective To investigate the relation between the homocysteine #8203;#8203;and pregnancy induced hypetension syndrome (PIH) as well as the mechanisms of blood plasma endothelin, nitrogen monoxidum in PIH. Methods 90 PIH women included 36 gestational hypertension, 30 mild preeclampsias, and 24 severe preeclampsias , and another 40 normal late term pregnant women as controls were recruited in this study. The plasma Hcy were determined by fluorescence polarization immunoass