Platelets and tissue factor.doc

 PAGE \* MERGEFORMAT 28 Platelets and tissue factor Abstract Tissue factor (tissue factor, TF) in blood coagulation and vascular thrombosis play an important role, not only exist in the extravascular tissue cells, but also present in circulating blood cells. Blood mononuclear cells can be induced by endotoxin expression of tissue factor. In recent years, many studies have shown that platelets on the P-selectin, CD40 ligand, and GP Ⅱ b / Ⅲ a receptor, also affect the expression of monocyte tissue factor. In addition, there is considerable evidence that, under physiological conditions, blood circulation there are tissue factor, platelet factor is part of the organization, its release under certain conditions to start the clotting reaction. In this paper, involved in blood clotting in platelets and tissue factor to make an overview of the relationship between the analysis. 【Key Words】 Platelet; tissue factor; coagulation; thrombosis Platelet and tissue Factor - Review Abstract It is generally accepted that tissue factor plays an important role in coagulation and intravascular thrombus formation. Tissue factor is not only found primarily on the surface of certain cells that are located outside the vasculature, but also found in circulating cells. Monocyte express tissue factor induced by endotoxin. Recently, many researches indicate that P-selectin, CD40 ligand and GP Ⅱ b / Ⅲ a receptor of platelet can also affect expression of tissue factor by monocyters. In addition, a lot of studies showed that tissue factor exist in the circulation including contained platelet. Tissue factor in the platelet releases under certain condition, and initiates coagulation. In this review the relation between platelet and tissue factor was elaborated. Keywords: platelet; tissue factor; coagulation; thrombus formation The main physiological role of platelets involved in normal hemostasis to prevent blood loss after injury, platelet adhesion, a