PNS mesangial proliferative glomerulonephritis model rats hemorheology.doc

 PAGE \* MERGEFORMAT 8 PNS mesangial proliferative glomerulonephritis model rats hemorheology Study: Dan Chung Liu Mingping Zou Yiping Chen Xiaoli [Abstract] Objective To observe the PNS on mesangial proliferative glomerulonephritis (MsPGN) Rheology of rats. Methods Serum pharmacological method, preparation of PNS containing serum, its divided into low, medium and high dose gradient 3, rats were observed on the Rheology of MsPGN by Plymouth Health LBY N6A self-cleaning rotary viscometer for hemorheology. The results can PNS improved hemorheology rats, compared to between three groups a significant effect on the high dose group. Conclusion PNS improved or stabilized their renal function improved in vivo mechanism of micro-circulation, lower blood hypercoagulability states. [Keywords:] PNS; mesangial proliferative glomerulonephritis; hemorheology Patients with chronic kidney disease was the hypercoagulable state, this hypercoagulable state is sustainable development of chronic kidney disease and decreased kidney function of important factors, hypercoagulability Early intervention can effectively control the progress of the disease and protect renal functions. At present, most clinical use of dipyridamole, aspirin and heparin and other anticoagulant and fibrinolytic drugs, but more side effects. notoginseng saponins are widely used in cardiovascular disease prevention, and many have oxygen free radicals, expansion of heart and brain blood vessels, lower blood pressure and improve heart and brain blood circulation, inhibit platelet aggregation, reduce blood viscosity and so on (1,2). This article will further explore the PNS on renal mesangial proliferative glomerulonephritis (MsPGN) Rheology of rats. 1 Materials and methods 1.1 Animals and grouping 72 SD rats, male, SPF grade, weighing 180 ~ 200 g, from Guangzhou University of Traditional Chinese Medicine Experimental Animal Center, qualified No.: 0002821, license number: SCK (Guangdong) 2003 000