Prevention and treatment of chronic gastritis gastric Capsule Pharmacodynamic Study.doc

 PAGE \* MERGEFORMAT 6 Prevention and treatment of chronic gastritis gastric Capsule Pharmacodynamic Study [Abstract] Objective To observe the stomach Capsule chronic gastritis, gastric ulcer in rats. Methods flooding - restraint stress rat model of gastric ulcer, acid alcohol-induced acute gastric mucosal injury model, as well as pain induced by acetic acid 0.6% in France. Results stomach Capsule 0.28,0.84 g / kg, can be significantly reduced gastric mucosal damage in rats with experimental damage index, lower total acidity of gastric juice and pepsin activity and have some analgesic effect. Conclusion Weishu capsule of chronic gastritis, gastric ulcer significantly in rats. [Keywords:] stomach Capsule pharmacodynamics of chronic gastritis Stomach Capsules are by the dandelion, astragalus, berberine, Yuan Hu, ginseng and other traditional Chinese medicine compound consisting of agents, with a heat-clearing and detoxifying, Rougan and stomach, spleen Qi, Qi and analgesic effect, mainly for chronic gastritis, gastric ulcer treatment. Preliminary work to prove the drug on the Helicobacter pylori-associated gastritis has obvious protective effect [1 ~ 3], for the systematic evaluation of its role, the author carried out its pharmacodynamic studies. Are reported below. 1 Materials and methods 1.1 Drugs and reagents Weishu capsules (0.4 g / grain, dandelion, berberine, ginseng, etc.), provided by the research group; 39 Wei-tai capsule (0.5 g / grain), the Nanfang Pharmaceutical Factory; Yuan Hu painkillers, Guangxi semi-chou Pharmaceutical Co., Ltd.; hydrochloric acid (AR), Shijiazhuang Hongqi Chemical Factory; anhydrous ethanol (AR), Beijing Chemical Plant. 1.2 Animals SD rats (2), weighing 180 ~ 220 g, male; Kunming mice (2), weighing 18 ~ 22 g, male and female in half, by the Experimental Animal Center of Hebei Province, permit No. SCXK (Hebei) 2003  1  003, animal feed from the center. 1.3 Methods 1.3.1 Stomach Capsules on rat flooding - the impact