Pre-eclampsia peripheral blood immune-associated genes differentially expressed in.doc

 PAGE \* MERGEFORMAT 5 Pre-eclampsia peripheral blood immune-associated genes differentially expressed in Authors: Bo Sun Zhenggui Qin Zhao Weihua Gao Su-qing Zhang Yuan [Abstract] Objective To understand the pre-eclampsia in patients with immune-associated genes differentially expressed, and explore its relationship with the pathogenesis of pre-eclampsia. Methods 4 cases of patients with severe pre-eclampsia as a research object, four cases of normal pregnant women as controls, two groups of gene chip technique for detecting differences in gene expression in peripheral blood of pregnant women to understand the peripheral blood of pre-eclampsia abnormal expression of immune-related genes. Results in the detection of 21000 genes, emerged two times to repeat the same differential expression of immune-related genes a total of 33, pre-eclampsia group of 23 up-regulated genes differentially expressed, down-regulated genes 10. Conclusion differential expression of immune-related genes may be one of the reasons the incidence of preeclampsia. [Keywords:] pre-eclampsia oligonucleotide sequence analysis of differentially expressed gene immunization [Abstract] Objective To investigate the differential expression of immunity-related genes in peripheral blood leucocytes between preeclampsia and normal pregnancy cases, and to explore the pathogenesis of preeclampsia. Method The differential gene expression files of 4 severe preeclampsia and 4 normal pregnancy cases were studied using cDNA array technique in order to identify the differential expression of immunity-related genes. Results 33 differentially expressed immunity-related genes had the concordance in at least 2 cases among total 21000 genes. 23 genes were up-regulated and 10 were down-regulated . Conclusions Differential expression of immunity-related genes in peripheral leucocytes from preeclampsia may be responsible for the molecular mechanism of preeclampsia. [Keywords:] Preeclampsia Differential expression