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Pre-gel starch and rapidly disintegrating tablets by King to the application of pain
PAGE \* MERGEFORMAT 4
Pre-gel starch and rapidly disintegrating tablets by King to the application of pain
Author: Gao Yong-Rong Zhang Ye Zhang Heming
[Keywords:] Pre-gel starch
To pain tablets by aminopyrine, phenacetin, caffeine, phenobarbital composed of compound preparation, with antipyretic, analgesic and anti-rheumatic effect. Quality Execution: The People’s Republic of China Ministry of Health, Drug Standard WS1-15 (B) -89. In addition to determination, the tablet disintegration time and friability are two very important indicators of quality control, but were found in the production of purchased raw materials because of the different drug manufacturers, these two indicators is sometimes difficult to compliance at the same time, To improve tablet prescriptions, pre-tests had used starch (in Canada) and the combination of sodium carboxymethyl starch, Friability good, but it failed disintegration time, even if the King plus 1% of the rapidly disintegrating disintegration time is still longer, and sometimes failed. Accessories will be changed within the Canadian starch, dextrin, or both a certain percentage friability were unqualified, when the disintegration of a large quantity of substandard dextrin.
To improve the quality of tablets by orthogonal test adding an appropriate amount of starch, pre-gelling starch and rapid collapse of the Queen selected the best prescription, by the experimental verification of the indicators are qualified, stable quality, suitable for industrial production.
An instrument and Drug
ZP-19 type rotary tablet machine (Shanghai United Pharmaceutical Machinery Factory); YK-160 swing-type particle machine (Shanghai Pharmaceutical Machinery Co., Ltd. Taiwan Tienhsiang Kin); 78X-2-type tablets with four detector (Shanghai Yellow doping Instrument Factory); Amidopyrine (Shandong Xinhua Pharmaceutical Co., Ltd.); phenacetin (Jiamusi Lu Ling Pharmaceutical Co., Ltd.); caffeine (Shandong Xinhua Pharmaceutical Co., Ltd.); phenobarb
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