Porous biphasic calcium phosphate ceramics in posterior spinal fusion of bone formation and degradation characteristics of histological.doc

 PAGE \* MERGEFORMAT 9 Porous biphasic calcium phosphate ceramics in posterior spinal fusion of bone formation and degradation characteristics of histological Author: Xie young professionals, ZHU Zhen, Zhang Pu, Maxine Hong Kingston, Jian-Xi Lu, Ke-Rong Dai [Abstract] [Objective] To understand the porous biphasic calcium phosphate ceramic in human posterior spinal fusion in the bone changes and degradation. [Method] 20 patients with posterior spinal fusion in biphasic calcium phosphate ceramic biopsy specimens were not decalcified hard tissue biopsy. Observed around and inside the new ceramic organization, ceramic patterns change, degradation of particles and associated phagocytic response. Including 14 cases of specimens histomorphometry, according to patient’s age, implant time and clinical outcomes compared groups into the bone and material degradation speed. [Results] All of the biphasic calcium phosphate ceramic specimens were seen new bone tissue, and autologous bone contact with the more new bone tissue within the ceramic more. Degradation seen in most of ceramic particles, some particles in the macrophages. Different specimens and material degradation rate of new bone quite different. Ceramics within the new bone increased with the implantation time increased, but with the reduction in the increase of age of the patient. Ceramic degradation rate increases with the age of the patient decreased, but not by time of implantation. Successful posterior fusion group of biopsy specimens is higher than the amount of new bone fusion failure group, but the material degradation rate is opposite. [Conclusion] The porous biphasic calcium phosphate ceramic is a kind of bone conduction material, but in vivo degradation of implanted slow new bone tissue that can not be completely replaced. Ceramic implants must be well mixed with autologous bone to achieve a good bone ingrowth. Produced by degradation of ceramic particles and phagocytic response must be induced by a