Prevention and treatment of tetramine poisoning.doc

 PAGE \* MERGEFORMAT 6 Prevention and treatment of tetramine poisoning [Keywords:] tetramine poisoning; diagnosis; prevention and treatment Tetramine poisoning because of the strong, the chemical nature of the extremely stable, not easily degradable in the environment is the use of governments banned the production of goods. However, some remote areas, continue to be poisoning incidents. Based on the literature data, its physical and chemical properties, toxicological, clinical manifestations, diagnosis, treatment and first aid measures based on a comprehensive order. A physical and chemical properties of tetramine The chemical name of tetramine dimethyl sulfoxide 4 4 Asia ammonia (C4H8N4O4S2, TEM), also known as 424, rats lose one’s life, special effects such as rodent Ling. Tetramine Department of white powder, odorless, slightly soluble in water, hardly soluble in alcohol and methanol, soluble in benzene, acetone and chloroform, dioxane and other organic solvents. Chemical properties of extremely stable, melting point 250 ℃ ~ 254 ℃ , 255 ℃ ~ 260 ℃ decomposition [1]. 2 tetramine toxicity Tetramine strong virulence, is a disabling nature of highly toxic rodenticide. Toxic to almost all warm-blooded animals, rodents LD50 of 0.1 ~ 0.3 mg / kg, its toxicity is the arsenic (As2O3) 114 ~ 138 times the potassium cyanide in 100 times. Do the same projections, about 1 mg can cause death. Because of its special structure, the chemical nature of the extremely stable, not easily degradable, easy to cause secondary poisoning, but also within the absorption of toxic plants (tests showed that with its deal with the soil, the growth of fir four years after the bear can still kill the pine vole) [2]. 3 Toxicology 3.1 The mechanism of tetramine poisoning are central nervous system inhibitory neurotransmitter γ -aminobutyric acid (GABA) antagonist. Can block the inhibitory neurotransmitter GABA to the neurons (this effect was reversible [1]), exciting the central ne