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Pre-oxygen on cerebral cortical neurons injury
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Pre-oxygen on cerebral cortical neurons injury
[Abstract] the effects of different concentrations of pre-oxygen, hypoxia and reoxygenation on cerebral cortical neurons injury. Methods: 72 adult male Wistar rats were randomly divided into A, B, C 3 groups, each group was divided into four subgroups. A Ⅰ ~ A Ⅳ (pre-oxygen) inhalation of sub-groups were 21%, 50%, 75% and 95% oxygen-30min; B Ⅰ ~ B Ⅳ (pre-oxygen hypoxia) subgroup A group approach by inhalation of 5% oxygen and then 20min; C Ⅰ ~ C Ⅳ (pre-oxygen hypoxia-reoxygenation) sub-group method of treatment according to group B, then 98% oxygen inhalation 20min. Cerebral cortex of rats in each group to take to measure lactic acid (LA), malondialdehyde (MDA), oxygen free radicals (OFR), total antioxidant capacity (T AOC), total superoxide dismutase (T SOD), catalase (CAT), glutathione peroxidase (GSH Px) and amino acid content, or viability. By immunohistochemical staining of inducible nitric oxide synthase (iNOS). In the light microscope observation of morphological changes of neurons. Results: A Ⅰ , A Ⅱ sub-group of neurons no significant change, A Ⅲ , A Ⅳ sub-group of neurons in mild swelling. B group neurons swelling Evidently, B Ⅲ , B Ⅳ subgroup is more serious. C group neurons in the nucleus condensation, nucleolus reduced and disappeared, of which the lightest C Ⅱ subgroup, C Ⅲ , C Ⅳ sub-group of the most weight, that even the nuclear cracking, disappear, only the outline of the residual cell ghost cell. Compared with the A Ⅰ Asia, A Ⅲ ~ A Ⅳ subgroup OFR, iNOS, and LA increased (P amp;lt;0.05), prompted the three factors involved in the injury of brain damage; T AOC increased (P amp;lt;0.05), may be damage factor is due to rise to the feedback of certain antioxidant factors of increase; T SOD reduced (P amp;lt;0.05), may be related to an increase in the consumption. C Ⅰ ~ C Ⅲ subgroup of OFR and C Ⅰ , C Ⅳ subgroup of iNOS, as well as C Ⅱ
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