Portal hypertension develop a large animal model of progress.doc

 PAGE \* MERGEFORMAT 20 Portal hypertension develop a large animal model of progress [Keywords:] portal hypertension large animal model For the manufacture of animal models of portal hypertension is the most commonly used mouse and rabbit animal, but who wish to surgical patients with portal hypertension of the way, the small animal model is difficult to achieve the desired results and the operation is inconvenient, so choose an ideal large animal model of portal hypertension, surgical treatment for the evaluation of the effect is very important. Over the years, prepared by scholars of a variety of major portal hypertension animal model, each method has its advantages, but also has its limitations, are summarized below. 1 prehepatic portal hypertension model-based production 1.1 The production model of portal vein narrowing Some narrowing of the portal vein can reduce the portal vein diameter, the blood returning blocked leading to increased portal pressure .1980 on Van Thiel [1] first reported this method: put a blunt No. 20 needle vertically placed directly next to the portal vein trunk with silk thread to the portal vein and the needle straight out straight after the ligation of needles, can cause a degree of stenosis of portal vein in order to establish animal models of portal hypertension. in theory, completely blocked the portal vein of portal vein pressure can rise up, but a complete portal vein ligation can lead to severe gastrointestinal congestion and hepatic ischemia, in addition to rhesus monkeys almost without exception lead outside the experimental animals died. national scholar Li Zongfang [2] by portal vein constriction 1 / 2-silk cord of chronic embolism method, an operation successfully and gradually completely blocked the portal vein, hepatic dog made a successful pre-type model of portal hypertension. postoperative animal survival rate was 95.5%, after 2 weeks portography see the trunk has been blocked, after 3 portal pressure