Plasmodium sexual differentiation and development of.docVIP

 PAGE \* MERGEFORMAT 13 Plasmodium sexual differentiation and development of Keywords:: Plasmodium Sexual differentiation and development in the malaria parasite’s life cycle plays an important role. Plasmodium is a vertebrate host in vivo to differentiate into semifinal gametophyte of (sexual issues), although this period is not directly caused by the parasite itself, the clinical symptoms, but they allow the parasite through the mosquito host and continued to spread in the vertebrate. Plasmodium sexual differentiation and development of the whole process according to different stages of maturity can be divided into induction, differentiation, and further mature in three steps, but still know very little about the molecular basis. It concluded that there were some in the natural environment may be the original signal, which switches in certain genes, and these genes determine the parasite entering the sexual phase, differentiation develop into the gametophyte, or continue to remain in the vegetative phase develop into schizonts sub. In addition, the expression products of these genes may also decide to female gametophyte. Sexual differentiation is dependent on a number of gender-related gene expression in series, including a number of sexual stage-specific genes and their protein product. However, these genes have been cloned and its protein product in the differentiation of malaria parasites in the role has been clarified in detail and only a small number of cell. When the mature female gametophyte mosquito exposure, we have taken a brief and rapid formation of gametes (10-20 minutes), resulting in semifinal gametes. A female gametophyte to form a female gamete, while a male gametophyte by mitosis to form the three eight male gamete. Male and female gametes produce fertilized zygote (the only diploid phase), and then quickly meiosis into haploid phase, the formation of oocysts. Oocysts produced in mosquito salivary gland sporozoite inflow to wait when the