Plaster compound berberine in percutaneous absorption of berberine.doc

 PAGE \* MERGEFORMAT 10 Plaster compound berberine in percutaneous absorption of berberine Of: Shi Wei, Liu Zhiqiang, Wang Shumin, leather phoenix [Abstract] Objective Azone on the transdermal absorption of berberine in vitro effects of berberine compound balm for the absorption enhancers through the film selection and provide the basis for production quality control. Methods for the experimental mice skin barrier, the use of ZTY transdermal experimental apparatus and the intelligent high performance liquid chromatography (HPLC assay to study Azone in combination with borneol when transdermal absorption of berberine. results when a certain amount of ice and the concentration was 0% 2%, 5% Azone joint use, berberine hydrochloride transdermal absorption rate constants were 62.591,52.927,60.622 g cm-2 h-1. Conclusion Borneol with different concentrations of Azone in combination when Azone and borneol have a certain mutual inhibition, the concentration of 0% Azone, there’s largest transdermal absorption rate constant. [Keywords:] balm, percutaneous absorption, HPLC, berberine Abstract: ObjectiveTo study the effects of azone on the percutaneous of berberine hydrochloride in vitro so as to provide experimental basis for complex prescription Coptis chinensis plastics to choose absorb promoter and control production quality. MethodsWith the skin of nude mice as the barrier, ZTY intelligence permeation skin tester and detection of HPLC were used to study the effects of coalition utilization of azone and borneol for percutaneous absorption of berberine hydrochloride in vitro. ResultsThe rate constants of berberine hydrochloride were 62.591,52.927 and 60.622 g cm-2 h-1 respectively when azone and borned of 0,2%, 5% were used together.ConclusionAzone with different concentration and bornel inhibit each other when they are combinedly used.The absorption rate is maximum when azone is 0%. Keywords:: Plastics; Percutaneous absorption; HPLC; Berberine hydroch