Probucol United atorvastatin in elderly patients with unstable angina treatment.doc

 PAGE \* MERGEFORMAT 7 Probucol United atorvastatin in elderly patients with unstable angina treatment [Keywords:] coronary artery disease, lipid-lowering drugs, high sensitive C-reactive protein, probucol Unstable angina (UA early cardiovascular events in patients with high risk of recurrence. Have been found in patients with coronary vascular endothelial function and the incidence of cardiovascular events are closely related, so the intervention on endothelial function may reduce the risk . a large number of studies have confirmed that early, intensive statin therapy can reduce the mortality of patients with UA, and its prognostic impact of UA is an important mechanism for vascular endothelial function by improving their (1). Probucol addition to lipid-lowering effects, or recognized anti-oxidant drugs and can improve endothelial function in patients (2). Probucol, aspirin and statins (PAS) triple therapy is necessary for symptomatic treatment of cerebral arteriosclerosis, but also prevent further ischemic events in the narrow and their corresponding effective method, PAS treatment of UA, particularly in the elderly application of concern. In this paper, elderly patients with carotid artery plaque on the changes and serum high sensitive C-reactive protein (hs CRP levels of intervention, to explore its of UA patients with early atherosclerosis and its possible mechanism. 1 Subjects and methods 1.1 Object Randomly selected inpatient and outpatient hospital 60 cases of elderly patients with UA were frequent performance of recent angina, according to the nature of pain, time and extent, and by ECG and troponin T, creatine kinase and other excluded the diagnosis of acute myocardial infarction UA. 42 males and 18 females, aged 70 to 89 years old, were randomly divided into conventional therapy group (30 cases Aspirin 100 mg / d and atorvastatin 20 mg / d and the PAS group (30 cases probucol 500 mg / d, Aspirin 100 mg / d and atorvastatin 20 mg / d. t