Procaterol capillary chromatography of organic solvent residue.doc

 PAGE \* MERGEFORMAT 8 Procaterol capillary chromatography of organic solvent residue [Abstract] Objective: To establish a capillary gas chromatography procaterol in the residual organic solvents. METHODS: Agilent INNOWax capillary column, FID detector and acetonitrile as the internal standard were determined. Results: The hexane, ethyl acetate ester, pyridine linear range of 0 ~ 464 g / mL (r = 0.999 9), 0 ~ 800 g / mL (r = 0.999 8), 0 ~ 32 g / mL (r = 0.999 3), the average recovery rates were 99.8%, 100.5%, 101.3%, RSD was 0.96%, 1.38%, 2.18% (n = 9). Conclusion: The capillary gas chromatography is simple, accurate, sensitive, reproducible, and applicable to c Cartro in the determination of residual organic solvents. [Keywords:] procaterol; capillary gas chromatography; organic solvent residue Abstract Objective: To develop gas chromatography method for determination of the residual organic solvents in procaterol. Methods: The samples were injected into Agilent INNOWax capillary column. And analysed with FID detector using acetonitrile as the internal standard. Results: The linear ranges of hexane, ethyl acetate and pyridine were 0 ~ 464 g / mL (r = 0.999 9), 0 ~ 800 g / mL (r = 0.999 8) and 0 ~ 32 g / mL (r = 0.999 3), respectively. The recoveries were 99.8 %, 100.5%, and 101.3% with RSD 0.96%, 1.38%, and 2.18% (n = 9), respectively. Conclusion: The method is simple, accurate and sensitive with good reproducibility. It can be used for determination of the residual organic solvents in procaterol. Keywords: Procaterol; Capillary gas chromatography; Residual organic solvents Procaterol (procaterol) is the 3rd generation of new drugs to be sympathetic 2 receptor, the 2 receptor on airway smooth muscle has a higher selectivity, while the excitability of the heart is weak. Dose of only tens of micrograms , can have a strong effect, and the long duration for the treatment of bronchial asthma, asthmatic bronchitis and chronic obstructive pulmonary dis