Process factors on ultrasound - extrusion filters Preparation of β-elemene solid lipid nanoparticles of average particle size.doc

 PAGE \* MERGEFORMAT 18 Process factors on ultrasound - extrusion filters Preparation of β-elemene solid lipid nanoparticles of average particle size Author: Wang Zhi, ZHOU Xin-yu, Cheng A letter, Bi Dian Zhou, Tang Yi-hui 【Abstract】 Objective To study the process factors on β-elemene solid lipid nanoparticles (SLN) average particle size effects. Methods Ultrasound - extrusion filters Preparation of β-elemene SLN, study of ultrasonic intensity, ultrasonic time and temperature factors on the preparation of average particle size effects. The results of the vast majority of β-elemene SLN, the average particle size of less than 150 nm. The average particle size with the extension of ultrasonic time and preparation temperature increased and decreased, but by the continuous ultrasonic time less affected. Inspection preparation, in the ultrasonic intensity of 400W, ultrasonic temperature of 80 ℃, ultrasonic time of 6 min under the conditions of preparation of β-elemene SLN average diameter of the smallest. Conclusion Ultrasound - squeezing filtration method can be prepared by β-elemene SLN, ultrasonic intensity, the overall ultrasonic time and temperature that affect the average particle size of the main technological factors. Technological Factors Keywords: β-elemene solid lipid nanoparticles ultrasound - squeezing filtration method Abstract: ObjectiveTo study the influence of the technological factors on the mean particle size of β-elemene solid lipid nanoparticles (SLN). Methodsβ-elemene SLN were prepared by the method combining sonication and membrane extrusion. Effects of the technological factors on the mean particle size of β-elemene SLN were studied, including sonication strength, total period of sonication length and preparation temperature, etc. ResultsThe results showed that most mean diameter of β-elemene SLNs was less than 150nm. The size of β-elemene SLN decreased with the increase of the total period of sonication length or the