Preventive effects of gastrodin efficacy evaluation of migraine and its mechanism.docVIP

 PAGE \* MERGEFORMAT 9 Preventive effects of gastrodin efficacy evaluation of migraine and its mechanism Study: High-Yong Gao Ying Liu Huilan Caoke Gang [Abstract: Objective Gastrodine on the prevention of migraine and its effects on rat brain monoamine neurotransmitters. Methods Gastrodin prophylaxis 5 d, in the first 5 days after administration of subcutaneous injection of nitroglycerin Copy migraine model, and observe their ears red and scratching behavior frequency indicators, using high performance liquid chromatography in rat brain tissue in each group of 5 - serotonin, norepinephrine and dopamine levels. Results Gastrodine red ear migraine rats, scratching and other behavior intervention effect, significantly increased rat brain 5 - HT, dopamine and norepinephrine levels. Conclusions gastrodin can prevent migraine, this effect may be related to regulation the body of monoamine neurotransmitter release and metabolism to be restored, thus improving the function of the brain and vascular disorders. Keywords:] gastrodin migraine neurotransmitter in rats Abstract: Objective To research the effects and mechanism of gastrodin against migraine and on single amine neurotransmitter. Methods The model of nitroglycerin migraine was made after rat treated by gastrodin for 5 days, the time points of ear rubescence and the times of scratch head were observed to take as evaluation index of pharmacodynamic action, the concentration of 5-HT, NE and DA were measured in the brain with HPLC. Results Gastrodin could obviously prevent the attack of migraine and increase the concentration of 5-HT, DA and NE in the brain. Conclusions The effects of gastrodin against migraine is related with the concentration of 5-HT, DA and NE in the brain, gastrodin can regulate neurosystematic functions and enhance the secretion and metabolism of neurotransmitters. Keywords:: gastrodin, migraine, neurotransmitter; rat Migraine is a common clinical recurrent disease, were on o