Prevention of Xerostomia after radiotherapy Progress.doc

 PAGE \* MERGEFORMAT 18 Prevention of Xerostomia after radiotherapy Progress [Keywords:] nasopharyngeal carcinoma radiotherapy adjuvant chemotherapy adjuvant to prevent dry mouth Xerostomia after radiotherapy in NPC patients with one of the most common sequelae, serious impact on the survival of nasopharyngeal carcinoma patients after radiotherapy quality, and can lead to patients with chewing, swallowing dysfunction, affecting taste, talk and sleep, but also make oral easily damaged and diseased tissue. Xerostomia mainly caused by radiation therapy can cause damage to salivary gland function is currently no completely effective method of prevention and treatment. In recent years, because of the quality of life after treatment and organ function protection The importance of protection and mitigation of salivary gland damage, prevention of radiation xerostomia methods and techniques, has been attached. of radiation xerostomia now causes and prevention methods and new advances are reviewed. 1 radiotherapy induced xerostomia causes and clinical characteristics 1.1 xerostomia caused by radiotherapy because radiation is the face, neck joint field nasopharyngeal irradiation method often used in the main, almost the entire radiation field, including the parotid and submandibular gland in the radiation therapy, usually make the parotid and submandibular gland by higher doses of radiation exposure. parotid gland is highly sensitive to radiation, and smaller amounts can cause damage to, studies have reported [1], after the start of radiotherapy patients, dry mouth, the median time for the first irradiation 4, conventional radiotherapy in 1 week (5 th and 2 weeks (10 times, respectively, 74% and 98% of the patients complained of dry mouth. At present, many agree that the parotid gland is radiation damage leading to cell apoptosis , some scholars believe that radiation therapy caused severe inflammation of parotid gland, the cell enzyme system damage, or gland