Progress thiols fluorescent probes_0.doc

 PAGE \* MERGEFORMAT 31 Progress thiols fluorescent probes Of: Ling Ling Chen Zhen Zhen Yin Tong Tsui Hark took Lili Tang Bo [Abstract] mercaptan is the organism in many proteins and small molecules important part of the antioxidant system in cells plays an important role in the quantitative detection of thiols in biochemistry and clinical chemistry is of great significance. Fluorescence due its high sensitivity, able to achieve even a single cell of live real-time visualization of the advantages of tracer into the widely used cellular thiols detected an important tool. This article references 51, by fluorescence probe Mechanism of thiol different categories to research progress in this area in recent years done a more systematic review and prospect of the development trend of such probes and applications. [Keywords:] mercaptan, fluorescent probe, review Abstract Thiols, which are components of many proteins and simple molecules, play an important role in the cellular antioxidant defense system. The quantitative determination of thiols is important in biochemistry and clinical chemistry. Fluorescent probes, which have its apparent advantages in sensitivity and, most importantly, in imaging thiols in vivo, even in single living cells, appear to be particularly attractive. In this review, we classify the fluorescent probes based on their different reaction mechanisms with thiols and summarize the recent progresses of thiols fluorescent probes with fifty one references . Particularly, the research actuality, the developing trends and prospects in the future were also discussed. Keywords Thiols, fluorescent probe, review 1 Introduction Mercaptan is the organism in many proteins and small molecules important part of the antioxidant system in cells plays an important role in [1]. Small molecule thiols including cysteine #8203;#8203;(Cys, glutathione (GSH, lipoic acid and coenzyme A; molecules containing thiol mercaptan, including peptides, enzyme