Promethazine injection in mice pre-injected foot ahead of the analgesic effect of formaldehyde.doc

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2017-05-05 发布于浙江
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Promethazine injection in mice pre-injected foot ahead of the analgesic effect of formaldehyde.doc

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Promethazine injection in mice pre-injected foot ahead of the analgesic effect of formaldehyde

Promethazine injection in mice pre-injected foot ahead of the analgesic effect of formaldehyde Of: Zhang Song, Fang Xin, Zhang Feng, Li Li, Zhou Yao, Hu Kaihua, Qi Yingjie, Wang Dan [Abstract] Objective To study whether a preemptive analgesia effect of promethazine. Methods Mice by stratified random block design into 3 groups: promethazine (5 mg kg-1) + pethidine (20 mg kg- Group 1 (P + D group, pethidine (40 mg kg-1) group (D group, saline group (NS group, n = 10. to formaldehyde in each group were observed 5 min after formalin injection in mice the licking time. Results P + D group and D group were licking time was significantly lower than the NS group (P lt;0.01, the difference between the two groups was not significant (Pgt; 0.05. Conclusions promethazine with the role of preemptive analgesia. [Keywords:] promethazine, preemptive analgesia, formaldehyde Abstract: Objective To investigate whether promethazine has the effect of preemptive analgesia. Methods 30 mice were divided into three groups by stratified random block design (n = 10, each): promethazine (5 mg kg-1) + pethidine (20 mg kg-1) group (P + D group), pethidine (40 mg kg-1) group (D group) and normal saline group (NS group). In the formalin test, subcutaneous injection of formalin was administered in the sole of mouse paw and the duration of paw-licking within 5 min was observed in each mouse. Result The duration of paw-licking was shorter in P + D group or D group than in the NS group (P lt;0.01), while there was no statistical difference between P + D group and D group (Pgt; 0.05). Conclusion Promethazine has the effect of preemptive analgesia. Keywords:: promethazine; preemptive analgesia; methanal Preemptive analgesia (preemptive analgesia) surgery by blocking transmission and inhibition of noxious stimulation of central sensitization to postoperative pain or pain relief to the purpose of [1]. Studies confirmed that some of the high selective histamine H1 by physical damage