Prunella pharmacological research_0.docVIP

 PAGE \* MERGEFORMAT 13 Prunella pharmacological research [Keywords:] Prunella, pharmacological action, review Labiatae Prunella Prunella Prunella vulgaris L. Plant dry ear, spicy, bitter, cold, hypoglycemic, antihypertensive, antibacterial, antiviral, anti-inflammatory, anti-tumor and blood circulation and other effects. As The important medicinal value and a wide range of pharmacological effects, so more and more cause for concern. Over the years, domestic and foreign scholars have done a lot of Prunella, I now at home and abroad in recent years, pharmacological studies of Prunella vulgaris an overview of the situation. A pharmacological effect 1.1 hypoglycemic Prunella has a significant hypoglycemic effect. Prunella alcohol extract can reduce the normal mice and alloxan diabetic mice blood glucose levels, elevated blood glucose may be against the adrenaline, and have improved glucose tolerance, increased glycogen synthesis role. Liu et al [1] that the mechanism may be related to insulin secretion or increase the conversion of glucose by the relevant organization. Zheng J et al [2] that by Prunella vulgaris extract may improve insulin sensitivity in vitro, effectively reduced blood glucose, glibenclamide can enhance the hypoglycemic effect. Lee et al [3] The streptozotocin (Strepotozotocin, STZ) received intravenous injection of diabetic mice, respectively, the amount of crude drug containing 8,4 g / kg alcohol extract, Green benzene or pure water fed urea experiments, found that inhibition of Prunella vulgaris extract has the role of hyperglycemia in diabetic mice, and showed significant dose-effect relationship, effect of high dose is better. The drop Sugar mechanism may Prunella vulgaris extract β cells through the repair or adjust the organization to increase insulin secretion glucose and lipid metabolism. 1.2 blood pressure lowering Prunella vulgaris extract can effectively lower blood pressure. Sun et al [4] found that the chlorofor