Progress in the Study of bacteria Integration.docVIP

 PAGE \* MERGEFORMAT 26 Progress in the Study of bacteria Integration [Abstract] integrons in recent years in bacteria found in a mobile gene elements, through site-specific recombination to capture and express the exogenous gene cassette, leading to drug resistance genes in bacteria levels between the spread of the important reasons for . In this paper, the discovery of integrons, structure, classification; gene cassette structure, origin; integron gene cassette on the capture, shearing and expression; integration of the child and the relationship between bacterial resistance and an integrated sub-test, etc. were reviewed. [Keywords:] integration of the child; gene cassette; resistance gene; drug resistance ABSTRACT Integrons are mobile DNA elements that were found in bacteria rencently. By capturing exogenous gene cassettes through site  specific recombination and ensuring the expression of genes contained in gene cassettes, integrons played important roles in the horizontal dissemination of drug  resistance genes in bacteria. This paper reviewed discovery, structure and classification of integrons, structure and origins of gene cassettes, the capture, deletion and expression of gene cassettes by integrons, the relationship between integrons and drug resistance, and the detection of integrons. KEY WORDS Integron; Gene cassette; Drug  resistance gene; Drug  resistance With the widespread use of antibiotics, bacteria in the choice of antibiotic resistant strains under the pressure of continuous production, in which bacteria through horizontal gene transfer, access to exogenous resistance genes is to accelerate the clinical drug-resistant strains of the important reasons. With the horizontal transfer of antibiotic resistance genes are closely related to the genetic structure of plasmids, transposons, integrated phage, as well as in recent years, a natural bacteria found in the cloning and expression system [1] - integrons (integron). Integrons cap