Pulverization on the dissolution characteristics of polysaccharides.doc

 PAGE \* MERGEFORMAT 10 Pulverization on the dissolution characteristics of polysaccharides Of: Gui Hui, Liangshao Yu, Lei Zhijun Cai light first [Abstract] Objective To investigate whether the ultra-fine powder will increase the dissolution of polysaccharides. Methods to sulfuric acid - phenol method, Determination of the content of polysaccharides, the use of pulp dissolution method, were fitted with Weibull model, for dissolution parameters T50 (50% drug dissolution time), Td (the time required for drug dissolution 63.2%), m (dissolution curve slope) for statistical analysis. Results Poria powder with different particle size of the parameter of polysaccharides difference between dissolution statistically significant (P lt;0.05). superfine powder and conventional parameters of the dissolution between the very significant (P lt;0.01). Conclusion Poria ultra-fine powder can improve the amount of medicine in the CMP and the dissolution rate of dissolution. [Keywords:] CMP, ultrafine grinding, dissolution, slurry Section Polyporaceae fungi Poria is dry sclerotia, of sweet, light, flat, heart, lung, spleen, kidney, diuresis with dampness, spleen and stomach, Ning Anshen and so on [1], a commonly used traditional Chinese medicine consisting mainly of polysaccharides (about 93% dry weight), triterpenes acetyl acid Poria, Poria acid, in addition to containing gum, chitin, protein, fat, sterol, lecithin, histidine, choline and lithium salt. Poria cocos polysaccharide as the main pharmacologically active ingredient, CMP by enhancing immune function, activated immune surveillance system, the inhibition of tumor cell DNA, RNA synthesis and other mechanisms, to play the role of anti-tumor [2], CMP also has anti- aging, antioxidant and so on. Some studies have shown, can only extract a small amount of water extraction of polysaccharides to powder medicine better. ultrafine grinding technology is the mechanical force by means of a special jet capacity or physica