Qidantongmai tablets on acute ischemia - reperfusion myocardial nitric oxide synthase system.docVIP

 PAGE \* MERGEFORMAT 13 Qidantongmai tablets on acute ischemia / reperfusion myocardial nitric oxide synthase system Of: EMERGENCY IN TRADITIONAL Wang, EMERGENCY Mutant Liu Jiayun [Abstract] Objective To observe Qidantongmai tablets on ischemia / reperfusion myocardial nitric oxide synthase (nitric oxide synthase, NOS). Methods to male SD rats were randomly divided into sham operation group, ischemia / reperfusion group, Qidantongmai tablets + ischemia / reperfusion group Ⅰ Qidantongmai tablets + ischemia / reperfusion group Ⅱ. Anesthetized rats by ligation of anterior descending coronary artery 40 mim, and reperfusion 4 h.TUNEL determination of myocardium apoptosis, colorimetric detection of myocardial tissue total nitric oxide synthase (NOS), inducible nitric oxide synthase (iNOS) activity and calculated structure nitric oxide synthase (cNOS) activity. the result of different doses of pre-Qidantongmai film inhibits ischemia / reperfusion myocardial apoptosis, the apoptotic index compared with the model group were significantly different (P lt;0.05, P lt;0.01). and the sham operation group, model group, the increase in myocardial iNOS activity (P lt;0.05), cNOS activity was decreased (P lt;0.01). Qidantongmai different doses of tablets to inhibit myocardial ischemia / reperfused rat iNOS activity (P lt;0.05), increased cNOS activity (P lt;0.05, P lt;0.01). Conclusion Qidantongmai tablets to inhibit ischemia / reperfusion myocardial apoptosis may be related to regulation of myocardial NOS organization’s activity. [Keywords:] Qidantongmai tablets, ischemia / reperfusion injury, myocardium, nitric oxide synthase, rat Ischemic heart disease is the nature of the pathological changes of myocardial ischemia and necrosis or apoptosis due to lack of oxygen, the early resumption of blood perfusion is the primary treatment of ischemic heart disease measures. However, as patients from reperfusion injury after ischemia-reflow were benefits the biggest obstacle.