Qin skin extract in mice with acute liver injury in experimental study.docVIP

 PAGE \* MERGEFORMAT 9 Qin skin extract in mice with acute liver injury in experimental study Author: Yinming Hao, Hui-son, Jiang Lijun, Jin-Chun-He, Li-ho Keywords: Qin skin;, acute liver injury;, the protective effect Abstract: Objective To study the Qin skin extract on carbon tetrachloride-induced acute liver injury in rats. Methods 60 male Kunming mice were randomly divided into normal control group, model control group, positive control group, medium and small-dosage group. Dazhong Xiao-dose treatment group respectively 2.0,1.0,0.5 g / kg ig Qin skin extract; positive control group by 0.1 g / kg ig silibinin; normal control group and model control groups to an equal volume of saline irrigation the stomach, a total of 6 d. The first 5 days, model control group, positive control group and treatment group by 2.0 ml / kg intraperitoneal injection of CCl4, the normal control group, intraperitoneal injection of an equal volume of saline. Comparison of each group alanine aminotransferase (alanine transaminase, ALT) superoxide dismutase (superoxide dismutase, SOD) and MDA (malondialdehyde, MDA) content. Results Qin skin extract can significantly reduce carbon tetrachloride-induced ALT levels in each group increased (P lt;0.05), at the same time be able to increase SOD activity and lower MDA content (P lt;0.05). Conclusion Qin skin extract on carbon tetrachloride-induced acute liver injury have some protective effect. Keywords:: Qin skin; acute liver injury; protective effect of Protective Effect of Ash Bark Extract Against Acute Liver Injury in Mice Abstract: ObjectiveTo investigate the protective effect of ash bark extract against carbon tetrachloride inducing acute liver injury in mice. MethodsSixty male mice were randomly divided into normal control group, model control group, positive control group, high-dosage group, middledosage group and lowdosage group . The mice in the above groups were fed for 6 days. The drug groups were