Qin-Ba Mountain pregnant human cytomegalovirus intrauterine infection with the UL54 UL97 gene mutation.docVIP
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Qin-Ba Mountain pregnant human cytomegalovirus intrauterine infection with the UL54 UL97 gene mutation
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Qin-Ba Mountain pregnant human cytomegalovirus intrauterine infection with the UL54 UL97 gene mutation
Author: Qiu-, Li Fen, YU Xue-wen, Li Qi, Han Zhen, Li Xue-cheng, Ren Hui
[Abstract] Objective To investigate the Qin-Ba mountain areas of pregnant women with gestation period of human cytomegalovirus (HCMV) intrauterine infection and HCMV UL54, UL97 gene mutation. Methods PCR detected 228 pairs of maternal serum and umbilical blood serum HCMV DNA, using pairs of HCMV DNA-positive restriction fragment length polymorphism (PCR RFLP) to detect HCMV UL54, UL97 gene 501,594 and 595 codon mutation has occurred. Results ① 228 pregnant women serum HCMV DNA positive in 19 cases, the positive rate was 8.33%; neonatal cord blood serum HCMV DNA-positive in 8 cases, the positive rate was 3.51%. In the 19 patients with HCMV DNA-positive pregnant women, their matching cord blood-positive in 7 cases, HCMV intrauterine transmission rate of 36.84%. ② HCMV DNA-positive pregnant women and their matching cord blood serum samples were not found positive for HCMV UL54, UL97 gene 501,594 and a mutation in codon 595. Conclusion Qinba Mountain HCMV higher incidence of intrauterine infection, its occurrence and HCMV UL54, UL97 gene mutation at codon 501,594 and 595 non-related, but does not rule out the existence of other sites of mutations or other forms of genetic abnormalities leading to virus-induced Diseases of the possibility of change.
[Keywords:] human cytomegalovirus; HCMV intrauterine infection; gene mutation
Human cytomegalovirus (human cytomegalovirus, HCMV) is a common cause of human congenital infection, one widespread in the population infected. After HCMV infection in pregnant women can cause miscarriage, premature birth, stillbirth, intrauterine growth retardation, neonatal congenital malformation, neonatal complications and long-term sequela. The topic of the Qin-Ba mountain past research surveys show that the HCMV infection rate of pr
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