Pulmonary surfactant therapy in 28 cases of neonatal respiratory distress syndrome.doc

 PAGE \* MERGEFORMAT 6 Pulmonary surfactant therapy in 28 cases of neonatal respiratory distress syndrome [Abstract] Objective To investigate the pulmonary surfactant (PS) of neonatal respiratory distress syndrome (NRDS) improvement of clinical manifestations of ventilator parameters and clinical significance. Methods From September 2002 ~ January 2009 admitted NRDS infants of 28 patients treated with Curosurf in the case were analyzed. Results after treatment l h, 6 h, 12 h, 24 h of inspired oxygen (FiO2) compared with before treatment there were significant differences (P lt;0.01) . children with mean airway pressure (MAP) decreased at 24 h in the drug significantly (P lt;0.05), end-expiratory pressure (PEEP) 1 h after administration is lower compared with before treatment there was significant difference (P lt;0.05 ). Conclusions PS no long-term adverse effects on children, safe, reliable, worthy of clinical application. [Keywords:] neonatal respiratory distress syndrome; pulmonary surfactant [Abstract] Objective To explore the clinical significance of the parameters changes and the clinical performance improvement of the pulmonary surfactant (PS) for the treatment of children with neonatal respiratory distress syndrome (NRDS). Methods We analyzed the treatment of 28 cases children with NRDS using the pulmonary surfactant (Curosurf) in our hospital from September 2002 to January 2009. Results The medication after l h, 6 h, 12 h, 24 h FiO2 had significant differences from that of pre medication (P lt;0.01). The mean airway pressure (MAP) of the patients decreased significantly 24 h after medication (P lt;0.05), PEEP decreased 1 h after medication and had significant differences from that of pre medication (P lt;0.05). Conclusion PS has no adverse effects on the children with NRDS and it is a safe and reliable method which is worth applying clinically. [Keywords:] Neonatal respiratory distress syndrome; Pulmonary surfactant Neonatal respiratory