Psoriasis patients with CXC-type chemokine receptor CXCR2 mRNA expression.doc

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2017-05-05 发布于浙江
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Psoriasis patients with CXC-type chemokine receptor CXCR2 mRNA expression.doc

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Psoriasis patients with CXC-type chemokine receptor CXCR2 mRNA expression

Psoriasis patients with CXC-type chemokine receptor CXCR2 mRNA expression Gui-Lan Yang, Chen Zhiqiang, Zheng Jia Yun, Li Xinyu, Chen Yun, Li Yu-mei, GAO Jian-ming [Abstract] Objective To determine the CXC-type chemokine receptor CXCR2 mRNA expression in psoriasis patients, ascertain that the receptor in patients with psoriasis The pathological physiological state, to explore its role in the pathogenesis of psoriasis. Method of reverse transcription - polymerase chain reaction (RT-PCR) method detected 33 cases of plaque-type psoriasis in patients with a view to pre-treatment site lesions, skin lesions around the appearance of normal skin and peripheral blood neutrophils, mononuclear cells and in the 16 patients treated to lesions subsided more than 70% of peripheral blood neutrophils and mononuclear cells in CXCR2 mRNA expression levels, and 30 healthy people set up the control group. The test results with the Psoriasis Area and Severity Index (PASI) and peripheral blood neutrophils, mononuclear cells, the expression level of the receptor expression levels and lesion site were carried out between the correlation analysis. Results parts of psoriatic lesions in the epidermis and dermis CXCR2 mRNA expression levels were 1.85 ± 0.76 and 1.23 ± 0.48, significantly higher than that of normal skin lesions around the appearance of the epidermis and dermis (respectively, 0.63 ± 0.48 and 0.86 ± 0.39; respectively P amp;lt;0.001, P amp;lt;0.01), and healthy controls in skin epidermis and dermis (respectively, 0.59 ± 0.21 and 0.55 ± 0.48, P all amp;quot;0.001), and are related to PASI was significantly positively related (epidermis: r = 0.86, P amp;quot;0.001; leather: r = 0.38, P amp;lt;0.05). Psoriasis patients with peripheral blood neutrophils in CXCR2 mRNA expression level of 1.45 ± 0.87, significantly higher than in healthy controls and patients after treatment (respectively, 0.74 ± 0.58, P amp;lt;0.001; 0.63 ± 0.58, P amp;lt;0.01), and with the PASI was signifi