Proliferation-suppressing gene expression in colorectal cancer and its significance.doc

Proliferation-suppressing gene expression in colorectal cancer and its significance Authors: Yi Jianzhong, Jiang Guang-Jian, LI Yu-hong 【Abstract】 Objective To investigate the proliferation of suppressor gene (HSG) expression in colorectal cancer and its significance. Methods Immunohistochemical staining HSG in colorectal normal mucosa, benign lesions and malignant tissues of the different expression of HSG. Results In normal mucosa, benign adenoma, colorectal carcinoma HSG positive expression rates were 94.2%, 74.2% and 50.9%, and normal mucosa and benign adenoma group, Group HSG expression in colorectal cancer rate has dropped, the difference was statistical significance (P lt;0.05); HSG protein expression and tumor differentiation had no correlation (Pgt; 0.05), with tumor lymph node metastasis and clinical staging closely related (P lt;0.05). Conclusion colorectal carcinoma HSG expression was significantly lower than benign adenoma and normal mucosa, suggesting that the evolution of HSG protein in colorectal cancer has important significance. Keywords: HSG; colorectal cancer; benign adenoma; of normal mucosa The proliferation of suppressor genes (hyperplasic suppress gene, HSG) is the Chen Guanghui, etc. [1,2] the use of mRNA differential display technology from normotensive and hypertensive rat vascular smooth muscle cells found in the new genes. Previous studies have shown that hypertension in animal models HSG active in the proliferation of vascular smooth muscle showed a low level of expression, and transfection of exogenous HSG can significantly inhibit the growth of vascular smooth muscle cells transfected HSG on a variety of exogenous tumor passage cell lines also have a significant growth inhibition and induction of apoptosis [3]. This article aims to observe the HSG in different tissues of colorectal changes HSG preliminary study on the impact of colorectal cancer evolution. 1 Materials and Methods 1.1 Clinical data Collection of