Prokinetic treatment of early severe abdominal injury in rabbit liver injury.doc

 PAGE \* MERGEFORMAT 14 Prokinetic treatment of early severe abdominal injury in rabbit liver injury Of: Xu Yan, Zhang Lianyang, Ma Xiaolin, guang [Abstract] Objective To investigate the early rabbit after severe abdominal injury mosapride treatment of intestinal motility promoting effect on liver injury. Methods BIM IV-type impact machine to establish biological impact injury in experimental animal model of abdominal, will 30 New Zealand rabbits randomly assigned to trauma, trauma prokinetic group and control group were observed in portal blood flow, serum total protein (TP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and liver generally and microscopic pathology. Results trauma and force the degree of portal venous flow decreased significantly smaller, serum alanine aminotransferase (ALT) elevated levels lower than the trauma group, and less liver damage. Conclusion rabbit severe thoracoabdominal Early after injury, and promote use of mosapride on gastrointestinal motility treatment have a role in reducing liver damage. [Keywords:] prokinetic agent, liver damage, abdominal injuries, mosapride Effects of prokinetics mosapride on liver injury in rabbits in early stage of severe thoraco abdominal injury XU Yan, ZHANG Lian yang, MA Xiao lin, JIANG Yao guang (Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China) Abstract: Objective To evaluate the effects of prokinetics-mosapride on liver injury in New Zealand white rabbits in early stage of severe thoraco abdominal injury. MethodsThe experimental model of thoraco abdominal injury was established. Thirty New Zealand white rabbits were randomly divided into control group, trauma group and mosapride treated group, and portal venous flow, serum TP, ALB, ALT, AST, morphological change of liver were measured. Results The degree of decreasing in portal venous flow and increase in AL