Rabbit VX2 renal carcinoma model and its imaging.doc

 PAGE \* MERGEFORMAT 11 Rabbit VX2 renal carcinoma model and its imaging Author: She Jun-Jun, Wang Ming, Cheng Wei, Dai Educational, Baizhi Lan, Che Xiangming [Keywords:] Magnetic resonance imaging Establishment of rabbit VX2 renal carcinoma model and its manifestations in imaging examination [Abstract] AIM: To establish rabbit VX2 renal carcinoma model and observe its manifestations in spiral CT, MRI and DSA. METHODS: VX2 renal carcinoma was induced in 20 New Zealand rabbits through VX2 carcinoma block transplantation, and then the carcinoma was examined through CT , MRI and angiography in different periods. RESULTS: Carcinoma formation rate was 100%. All the carcinomas were shown to be isointense or hypointense lesions through normal spiral CT. The carcinomas presented hypointense nodules and the enhanced edges through contrastenhanced spiral CT. The carcinomas presented comparatively uniform hypointense lesions in T1WI MR images and hyperintense lesions in T2WI MR images. Three weeks later, the carcinomas showed mixed nodules of hypointense and hyperintense because of liquefaction and necrosis. In renal artery angiography VX2 carcinoma showed hypervascular. CONCLUSION: The best stage for experimental researches of rabbit VX2 carcinoma model is 2-3 weeks after tumor transplantation. Spiral CT is suit to observe dynamicly and evaluate curative effect. The rabbit VX2 carcinoma model is fit for intervention research. [Keywords] VX2 kindey neoplasms; spiral CT; MRI; DSA; rabbit [Abstract] Objective: To establish a rabbit VX2 renal carcinoma model, observe the animal model of the spiral CT, MRI and renal artery angiography imaging. Methods: New Zealand white rabbits were 20 to take blocks of VX2 tumors into tumors growing methods, respectively, at different times row spiral CT, MRI and renal arteriography. Results: The composition of tumors was 100%. tumors, when the spiral CT scan showed equal or low-density lesion, the enhanced low-density nodule showed ma