Regulate the mitochondrial pathway Yiqijiedu block party Qi cancerous nasopharyngeal epithelial cells in rats exposed to happen_0.docVIP

 PAGE \* MERGEFORMAT 14 Regulate the mitochondrial pathway Yiqijiedu block party Qi cancerous nasopharyngeal epithelial cells in rats exposed to happen On: Sun Ying request, into thin Hua, Tin Road Law, Yu Rong, Hu Weicheng Fine China [Abstract] Objective To investigate the side Yiqijiedu deficiency by regulating the mitochondrial pathway blocked the occurrence of rats exposed to nasopharyngeal. Methods 72 SD rats were randomly divided into model group, party group, and retinoic acid Yiqijiedu group. Intraperitoneal injection Second-nitroso-piperazine (DNP) and phorbol ester (TPA), while the exhaustive swimming, nasopharyngeal rat model of RA Yiqijiedu side group and the group were given the appropriate drug intervention, regular rats were sacrificed in batches, taking the pathological examination of nasopharyngeal tissues, immunohistochemistry SABC method to detect protein expression, RT-PCR detection of mRNA. results in the process of nasopharyngeal induced simple hyperplasia stage, with the model group, side group and the retinoic acid Yiqijiedu rats nasopharyngeal epithelial cells Bcl-2, Bax, Cytochrome-C and Caspase-3 protein expression were not significantly different (Pgt; 0.05). and in dysplasia stage, the benefits gas detoxification side group nasopharyngeal epithelial cells Bcl-2 protein expression was significantly lower than model group (P lt;0.05), Cytochrome-C and Caspase-3 and were significantly higher than the model group (P lt;0.05), Bax protein activity Although higher than the model group, but more analysis showed that the difference between the groups but no statistical significance (Pgt; 0.05). in the same pathological stage of nasopharyngeal epithelial cells in each group Bax and Bcl-2 mRNA transcription activity and their protein expression activity showed parallel trends. Yiqijiedu conclusions can effectively block reverse side nasopharyngeal epithelial carcinogenesis process in rats, the role of effective regulation of the mitocho