Rectal cancer VEGF-C expression of CXCR4 and the clinical significance of.docVIP

 PAGE \* MERGEFORMAT 10 Rectal cancer VEGF-C expression of CXCR4 and the clinical significance of Of: Fu Wei, Li Aina, Xu Hong, Wang Yulan [Abstract] Objective To investigate the chemokine receptor CXCR4 (CXC chemokine receptor 4, CXCR4) and vascular endothelial growth factor-C (vascular endothelial growth factor C, VEGF-C) in human cancer tissues, adjacent tissues and lymph nodes and their significance. Methods Immunohistochemistry was used to detect 10 cases of adjacent normal mucosa, 50 cases of cancer and related lymph nodes CXCR4 and VEGF-C protein expression, and its relationship with clinicopathologic characteristics. Results CXCR4 and VEGF-C in rectal cancer have high expression, CXCR4 expression was 72%, VEGF-C expression was 92%, compared with adjacent normal tissues there were significant differences. metastatic lymph nodes The positive rate of CXCR4 expression in 95%, VEGF-C positive expression rate of 93%, compared with no lymph node metastasis were significant differences. both CXCR4 and VEGF-C expression and invasion of cancer tissues of different degree of , histological grade and pathological stage between the closely related and both were positively correlated. Conclusion CXCR4 and VEGF-C in colorectal cancer and metastatic lymph nodes was positively correlated, suggesting that CXCR4 and VEGF-C in colorectal cancer invasion, metastasis from synergies, may be used to evaluate lymph node metastasis in rectal cancer one of the indicators. [Keywords:] cancer; chemokine receptor CXCR4; vascular endothelial growth factor-C Abstract: Objective To investigate the expression of CXC chemokine receptor4 (CXCR4) and vascular endothelial growth factor C (VEGF-C) in human rectal tumor tissues, cancer adjacent tissues, lymph node and to explore the clinical significance. Methods The expression of CXCR4 and VEGF-C was determined by immunohistochemistry in adjacent normal mucosa of 10 cases and in rectal cancer tissues and relevant lymph nodes of 5