Regulation of Traditional Chinese Medicine of the progress of tumor immune escape.docVIP

 PAGE \* MERGEFORMAT 16 Regulation of Traditional Chinese Medicine of the progress of tumor immune escape [Keywords:] Chinese medicine, cancer; immune escape, review Tumor proliferation, invasion and metastasis process, that is, the tumor continued to evade the immune system to attack the process. Tumor immune escape mechanism is complex, involving both the body of tumor and tumor factors, some mechanism is not very clear, yet need further exploration. these mechanisms involves the following aspects [1]: ① the weak immunogenicity of tumor antigens and antigenic modulation, antigen covered or closed. ② cell surface major histocompatibility complex (MHC) molecule expression decrease or defect, or deal with presenting antigenic peptide platelet-activating factor (FDG), human immunoglobulin (HIG) and other defects, or tumor cells through the expression of non-classic histocompatibility antigen (HLA) molecules (such as HLA-G and HLA-E) to the natural killer cells (NK cells) to pass inhibitory signals, down the function of NK cells to evade NK cell attack. ③ B7/CD28/CTLA-4 and other costimulatory molecules expression of adhesion molecules decreased. ④ tumor cells can be a number of autocrine or paracrine immunosuppressive cytokines such as TGF-β, IL-10, PGE2 and so weaken the immune system effects on tumor rejection, or immune suppression by inducing cell induced immune suppression. ⑤ tumor cells can release soluble antigen and antibody combine to form complex, through the antibody Fc segment and lymphocytes, NK cells or macrophage Fc receptor, which closed ADCC effect. ⑥ soluble tumor cells activated receptor ligands, such as NK cell activation receptor NKG2D ligand MICA decreased activation of the immune cell surface receptor expression, the immune effector cell function is lost or dropped. ⑦ tumor cells with high expression of FasL, can be through the Fas / FasL pathway-mediated apoptosis of tumor-specific T cells, on the other hand, tumor cells with low ex