Regulatory T cells in their immune system#39;s role.docVIP

 PAGE \* MERGEFORMAT 30 Regulatory T cells in their immune system#39;s role Keywords: T-cell self-regulatory role of the immune system Steady-state control of the immune system is essential to the body. In the 1970s, discovered a kind of immunosuppressive nature of the T-cells - regulatory T cells (regulatory T cell, Treg), in recent years has become a hot research in the field of Immunology. Is now on the regulatory T cells (Treg) in its own role in the immune system related literature are reviewed. 1 regulatory T cells in the classification and function of Regulatory T cells can be divided into naturally occurring regulatory T cells, natural (nTreg) and induced adaptive regulatory T cells (aTreg or iTreg), such as Th3, Tr1, and there are still CD8 Treg, NKT cells and so on, and the occurrence of autoimmune disease closely related to its abnormal expression may lead to autoimmune diseases. 1.1 a natural regulatory T cells (nTreg) Mainly CD 4 CD 25 Treg. Sakaguchi et al [1] will be CD 4 CD 25Treg defective T-cells in mice transferred to nude mice can cause a variety of autoimmune diseases, while the pre-enter the CD 4 CD 25Treg can prevent the occurrence of such diseases; to normal mice The CD 4 T cells in the spleen to remove CD 25 cells transferred to syngeneic T-cell-deficient mice will lead to a variety of organ-specific autoimmune diseases (including type Ⅰ diabetes, thyroiditis and gastritis, etc.) and systemic diseases, consumption of , while the injection of CD 4 CD 25 cell population can inhibit the occurrence of these autoimmune diseases, which show that the first group of cells have the ability to regulate immunity. CD 4 CD 25 Treg in peripheral blood and spleen about CD 4 T cells in 5% ~ 10%, CD 4 CD 25 Treg among CD4 molecule and CD25 molecule expression, the symbol is characterized by its high expression of transcription factor Foxp3. Foxp3 not only as a CD 4 CD 25 Treg sign of elements, so we decided CD 4